Which of the following symptoms is commonly associated with Cushing syndrome?

Truncal obesity is a hallmark symptom associated with Cushing syndrome, which is a condition caused by prolonged exposure to high levels of cortisol. In Cushing syndrome, the abnormal accumulation of fat particularly around the trunk and abdomen is characteristic. This redistribution of fat often leads to a thin appearance in the limbs while the central body mass becomes increased, creating the distinctive “moon facies” and the truncal obesity observed in patients.

The other symptoms listed are not typically prominent in Cushing syndrome. For example, low blood pressure would be more commonly seen in adrenal insufficiency rather than hypercortisolism. Hyperpigmentation is typically associated with conditions like Addison’s disease, where increased levels of adrenocorticotropic hormone (ACTH) stimulate melanin production—this is less relevant in Cushing syndrome where cortisol levels are high. Fatigue may be present but is a nonspecific symptom that can relate to many conditions, making truncal obesity a more defining symptom of Cushing syndrome.