What is a symptom that is NOT associated with Addison's disease?

In Addison's disease, which is characterized by insufficient production of adrenal hormones, individuals commonly experience a variety of symptoms due to adrenal insufficiency. Fatigue, skin hyperpigmentation, and weight loss are all associated symptoms.

Fatigue arises because of the lack of cortisol, which is crucial for energy metabolism and stress response. Skin hyperpigmentation occurs due to increased levels of adrenocorticotropic hormone (ACTH), which stimulates melanin production when cortisol levels are low. Weight loss can also be a significant symptom, as the body's inability to regulate metabolism leads to decreased appetite and effective energy use.

In contrast, hyperglycemia is not typically associated with Addison's disease. In fact, patients with Addison's disease often experience hypoglycemia due to low cortisol levels, as cortisol normally helps maintain blood glucose levels by promoting gluconeogenesis in the liver. Therefore, recognizing hyperglycemia as not being related to Addison's disease is consistent with the pathophysiological mechanism at work in this condition.